刘新华，博士，教授，博导
安徽省特聘教授、安徽省学术与技术带头人、安徽省杰出青年基金获得者、安徽省战略性新兴产业技术领军人才、安徽省特支计划领军人才、安徽省教科文卫系统师德先进个人；安徽省药物化学专委会主任、安徽省药学会常务理事；SCI期刊Current Topics in Medicinal Chemistry 及Medicinal Chemistry编委。先后主持973子课题1项、国家自然科学基金4项、安徽省重大科技专项。以通讯作者在包括Medicinal Research Reviews、Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry等药物化学主流SCI期刊发表论文60多篇，其中：中科院小类一区Top论文20多篇；获新药先导化合物中国发明专利授权多项。安徽医科大学十佳教师、安徽医科大学优秀研究生导师、优秀研究生导师团队带头人，培养了安徽省第一位药物化学博士。先后获安徽省科技进步三等奖、安徽省青年科技奖。
研究方向：药物设计与合成/药物化学生物学
联系方式：邮箱： xhliuhx@163.com
主持课题：
1.国家自然科学基金面上项目：靶向Dyskerin-NOP10相互作用的特异性小分子：优化设计合成及抑制端粒酶活化 (21977001), 2020.1~2023.12
2.国家自然科学基金面上项目：选择性识别端粒蛋白p65的苯并吡喃新先导：优化设计合成及作用机制 (21572003), 2016.1~2019.12
3.国家自然科学基金面上项目：新型端粒酶TERT抑制剂：吡唑-香豆素-色酮新骨架的优化设计合成及构效关系 (21272008), 2013.1~2016.12
4.国家自然科学基金青年基金： 新型以手性2H吡唑-噁唑为中心多杂环的设计杀菌活性及构效系 (20902003), 2010.1~2012.12
5.安徽省杰出青年基金：合成药物化学 (1408085J04), 2014.7~2016.7
6. 安徽省重大科技专项：抗肿瘤药物合成的关键技术与产业化研 (18030801118), 2018.1~2020.12
部分发表文章：（10篇以内）
1) Yang Wang, Xing Chen, Yaoyao Yan, Ming ming Liu* and Xin Hua Liu*, Discovery and SARs of 5-chloro-N4-phenyl-N2-(pyridin-2-yl) pyrimidine-2,4-diamine derivatives as oral available and dual CDK 6 and 9 inhibitors with potent anti-tumor activity, Journal of Medicinal Chemistry, 2020, 63, 3327-3347.
2) Mingming Liu, Yuru Liang, Zhongzhen Zhu, Jin Wang, Xingxing Cheng, Jiayi Cheng, Binpeng Xu, Rong Li, Xinhua Liu* and Yang Wang*, Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-inducible Factor (HIF) 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis,Journal of Medicinal Chemistry, 2019,62, 9299-9314.
3) Xing Chen, Wen-Jian Tang, Jing Bo Shi, Ming Ming Liu, Xin Hua Liu*, Therapeutic strategies for targeting telomerase in cancer, Medicinal Research Reviews, 2020, 40, 532-585.
4) Jing Bo Shi, Liu Zeng Chen, Bao Shi Wang, Xin Huang, Ming Ming Jiao, Ming Ming Liu, Wen-Jian Tang and Xin-Hua Liu*, Novel Pyrazolo[4,3-d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model, Journal of Medicinal Chemistry, 2019,62, 4013-4031.
5) Liu Zeng Chen, Li Yao, Ming Ming Jiao, Jing Bo Shi, Yue Tan, Ban Feng Ruan*, Xin Hua Liu*, Novel resveratrol-based flavonol derivatives: synthesis and anti-inflammatory activity in vitro and in vivo,European Journal of Medicinal Chemistry, 2019, 175, 114-128.
6) Jie Quan Wang, Xiao bin Wang, Yang Wang, Wen JianTang, Jing Bo Shi, Xin Hua Liu*, Novel curcumin analogue hybrids: Synthesis and anticancer activity,European Journal of Medicinal Chemistry, 2018, 156, 493-509.
7) Xiu Cheng, Jing Bo Shi, Hao Liu, Liu Zeng Chen, Yang Wang, Wen Jian Tang*, Xin Hua Liu*, Discovery of (4-bromophenyl)(3-hydroxy-4-methoxyphenyl)
methanone through Up-Regulating hTERTInducesCell Apoptosis and ER stress, Cell Death & Disease, 2017,8, e3016.
8)Liu Zeng Chen, Wei Wei Sun, Li Bo, Jie Quan Wang, Cheng Xiu, Wen Jian Tang, Jing Bo Shi, Hai Pin Zhou, Xin Hua Liu*, New arylpyrazoline-coumarins: Synthesisand anti-inflammatoryActivity, European Journal of Medicinal Chemistry, 2017, 138, 170-181.
9) Yang Wang, Fei Xiong Cheng,Xiao Long Yuan, Wen Jian Tang, Jing Bo Shi, Chen ZhongLiao, Xin Hua Liu*, Dihydropyrazole derivatives as telomerase inhibitors: structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo, European Journal of Medicinal Chemistry, 2016, 112, 231-251.
10) Yan Yan Chen, Xiao Qin Wu, Wen Jian Tang, Jing Bo Shi, Jun Li, Xin Hua Liu*, Novel dihydropyrazole-chromen: Design and modulates hTERT inhibition proliferation of MGC-803, European Journal of Medicinal Chemistry, 2016, 110, 65-75.
1) 2013年获得第十五届安徽青年科技奖
2) 2014年获安徽省科技进步三等奖（第一完成人），具有药用价值的新型杂环小分子的设计合成与生物活性研究
3) 2017年获安徽省药学会第二届十佳青年药师
国家发明专利
1.刘新华; 石静波; 陈冉; 王宝石; 汤文建; 陈留赠; 汪洋; 一种嘧啶并吡唑杂环化合物、制备方法、用途，专利号：ZL201711446400.5