陈飞虎,博士,二级教授,博士生导师

安徽医科大学科技产业处处长,安徽省学术与技术带头人,安徽省高校教学名师,安徽省政协委员,安徽省药理学会理事长。主持《雌激素及其受体对ASIC1a介导的关节软骨细胞凋亡的保护作用及其机制》、《ASlC1a介导的自噬对佐剂性关节炎(AA)大鼠关节软骨细胞的作用及其机制》等国家自然科学基金5项、国家“十一五”计划科技重大专项“重大新药创制”专项项目1项、国家十二五计划科技重大专项“重大新药创制”平台项目1项、国家中医药行业专项1项,发表学术论文400余篇SCI论文100余篇,以第一完成人申请国家专利9项及美国专利、欧洲专利各1项。全国高校首批黄大年式教师团队-药学教师团队负责人。

 

研究方向:抗炎免疫药理学、分子药理学、临床药理学。

 

联系方式:邮箱:cfhchina@qq.com

 

主持课题:

1.国家自然科学基金,雌激素及其受体对ASIC1a介导的关节软骨细胞凋亡的保护作用及其机制,818739862019/01-2012/1257万元;

2.国家自然科学基金,ASlC1a介导的自噬对佐剂性关节炎(AA)大鼠关节软骨细胞的作用及其机制, 812717492017/01-2018/1225万元;

3.国家中医药行业专项,丹皮品种选育及种植质量控制技术研究,201507002-1-052015/01-2018/12107万元;

4.国家自然科学基金,ASICs 的表达与开放在佐剂性关节炎(AA)大鼠关节软骨细胞凋亡中的作用及其机制,812717492013-201670万元;

5.国家“重大新药创制”科技重大专项平台建设,企业创新药物孵化基地建设, 2011ZX09401-0212012-2014800万元(子项目负责人,240万元);

 

部分发表文章:(10篇以内)

1. Yihao Zhang, Xuewen Qian, Xiaojuan Yang, Ruowen Niu, Sujing Song, Fei Zhu, Chuanjun Zhu, Xiaoqing Peng, Feihu Chen. ASIC1a induces synovial inflammation via the Ca2+/NFATc3/RANTES pathway. Theranostics 2020; 10(1):247-264.

2. Renpeng Zhou, Tiandong Leng, Tao Yang, Feihu Chen, Wei Hu, Zhi-Gang Xiong. β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation. Stroke,2019 Oct;50(10):2902-2911

3. Ren-Peng Zhou, Bei-Bei Dai, Ya-Ya Xie, Xiao-Shan Wu, Zhi-Sen Wang, Yue Li, Zhi-Qiang Wang, Sheng-Qin Zu, Jin-Fang Ge, Fei-Hu Chen. Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel. Biochim Biophys Acta Mol Basis Dis,2018 Jan;1864(1):162-177.

4. Yan Du, Mei-Ju Zhang, Lan-Lan Li, Xiao-Lin Xu, Hao Chen, Yu-Bin Feng, Yan Li, Xiao-Qin Peng, Fei-Hu Chen. ATPR triggers acute myeloid leukaemia cells differentiation and cycle arrest via the RARα/LDHB/ERK-glycolysis signalling axis. J Cell Mol Med,2020 Jun;24(12):6952-6965.

5. Yubin Feng, Shuang Hu, Lanlan Li, Shengpeng Zhang, Jikang Liu, Xiaoling Xu, Meiju Zhang, Tianxi Du, Yan Du, Xiaoqing Peng, Feihu Chen. LncRNA NR-104098 Inhibits AML Proliferation and Induces Differentiation Through Repressing EZH2 Transcription by Interacting With E2F1. Front Cell Dev Biol,2020 Mar 26;8:142.

6. Yubin Feng, Lanlan Li, Yan Du, Xiaoqing Peng, Feihu Chen. E2F4 functions as a tumour suppressor in acute myeloid leukaemia via inhibition of the MAPK signalling pathway by binding to EZH2. J Cell Mol Med,2020 Feb;24(3):2157-2168.

7. Cong Wang, Ke Wang, Shu-Fang Li, Su-Jing Song, Yan Du, Ruo-Wen Niu, Xue-Wen Qian, Xiao-Qing Peng, Fei-Hu Chen. 4-Amino-2-trifluoromethyl-phenyl retinate induced differentiation of human myelodysplastic syndromes SKM-1 cell lines by up-regulating DDX23. Biomed Pharmacother,2020 Mar;123:109736.

8. Renpeng Zhou, Fei Zhu, Xiaoshan Wu, Sujing Song, Yong Chen, Chuanjun Zhu, Beibei Dai, Xuewen Qian, Ke Wang, Wei Hu, Feihu Chen. Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats. J Cell Mol Med,2019 Nov;23(11):7879-7884.

9. Xuewen Qian, Yihao Zhang, Jingjing Tao, Ruowen Niu, Sujing Song, Cong Wang, Xiaoqing Peng, Feihu Chen. Acidosis induces synovial fibroblasts to release vascular endothelial growth factor via acid-sensitive ion channel 1a. Lab Invest,2020 Aug 21.