汪佳男,女,博士,校聘副教授,硕士生导师
现为安徽医科大学药学院基础与临床药理教研室教师。主持国家自然科学基金青年项目,以第一作者或共同第一作者在Science Translational Medicine、Redox Biology、Acta Pharmacologica Sinica、International Journal of Biological Macromolecules发表SCI论文十余篇,研究工作被权威学术评价机构F1000点评并推荐,其中一篇入选ESI高被引论文。
主要研究方向:1.表观遗传学修饰与急慢性肾脏损伤;2.筛选抗急慢性肾损伤的潜在药物。
代表性文章:
1.Wang Jia-nan*, Meng Xiao-ming#, et al.Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms.Sci Transl Med. 2022 Apr 13;14(640):eabk2709. ESI高被引论文。
2.Wang Jia-nan*, Meng Xiao-ming#, et al. Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production. Redox Biol 2020; 32:101479.
3.Wang Jia-nan*, Meng Xiao-ming#, et al. RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress. Clin Sci (Lond) 2019; 133:1609-1627. F1000点评并推荐。
4.Yang Qin*, Wang Jia-nan*, Meng Xiao-ming#, et al. Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7. Clin Sci (Lond) 2020; 134:103-122.
5.Wang Fang*, Wang Jia-nan*, Meng Xiao-ming#, et al. Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis.Acta Pharmacol Sin 2022; 43:330-341.