李小枫,男,1988.01,博士,校聘副教授,硕士生导师。主持国家自然科学基金青年项目1项、博士后科学基金面上项目1项,以第一作者或共同第一作者发表SCI 10余篇。
研究方向:抗炎免疫药理学(类风湿性关节炎);分子药理学等。
邮箱:lixiaofeng@ahmu.edu.cn
主持科研项目:
1) 国家自然科学基金委员会, 青年科学基金项目, 82002269, m6A甲基化转移酶WTAP通过NLRP3介导的炎症小体促进类风湿性关节炎滑膜炎症反应及机制研究, 2021-01-01至2023-12-31;
2) 中国博士后科学基金会, 面上项目, 2020M671839, PCOLCE通过NLRP3介导的炎症小体抑制类风湿性关节炎滑膜的炎症反应, 2020-07至2022-06。
代表性文章:
1) Li XF#, Yin SQ#, Li H#, Yang YL, Chen X, Song B, Wu S, Wu YY, Wang H*, Li J*. PPAR-γ alleviates the inflammatory response in TNF-α-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis. Acta Pharmacol Sin, 2023 Feb;44(2):454-464.
2) Li XF#, Wu S#, Yan Q#, Wu YY, Chen H, Yin SQ, Chen X, Wang H*, Li J*. PTEN Methylation Promotes Inflammation and Activation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. Front Pharmacol, 2021 Jul 8;12:700373.
3) Li XF#, Chen X#, Bao J, Xu L, Zhang L, Huang C, Meng XM, Li J*. PTEN negatively regulates the expression of pro-inflammatory cytokines and chemokines of fibroblast-like synoviocytes in adjuvant-induced arthritis. Artif Cells Nanomed Biotechnol, 2019 Dec;47(1):3687-3696.
4) Li XF#, Sun YY#, Bao J#, Chen X, Li YH, Yang Y, Zhang L, Huang C, Wu BM, Meng XM, Li J*. Functional role of PPAR-gamma on the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. Sci Rep, 2017 Oct 4;7(1):12671.
5) Li XF#, Shen WW#, Sun YY, Li WX, Sun ZH, Liu YH, Zhang L, Huang C, Meng XM, Li J*. MicroRNA-20a negatively regulates expression of NLRP3- inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes. Joint Bone Spine, 2016 Dec;83(6):695-700.