硕士生导师---张煚副教授
发布时间:2024-03-28


张煚,博士,副教授,硕士生导师

本科毕业于西安交通大学制药工程专业,博士毕业于上海交通大学药学专业,中国科学院上海有机化学研究所化学专业博士后。现任职于安徽医科大学药学院和炎症免疫性疾病安徽省实验室。主要研究方向为结构多样性点击化学衍生物库的制备、生物活性小分子的发现与作用机制研究、基于靶标的虚拟筛选与药物设计、天然产物的结构优化,以及药物化学转化研究。主持国家自然科学基金、安徽省自然科学基金、安徽省高校科研重大项目等科研项目多项,在Proc. Natl. Acad. Sci.J. Med. Chem.Sci. China Life Sci.Eur. J. Med. Chem.Bioorg. Chem.Sci. China Chem.等期刊发表研究论文20余篇,申请专利多项。指导研究生获校科研与实践创新项目2项,指导本科生获大学生创新创业训练计划国家级、省级和校级立项各2项,指导本科生获挑战杯大学生创业计划竞赛校级二等奖和三等奖各1项,指导本科生获国际大学生创新大赛校级银奖和铜奖各1项。

邮箱:zhangjiong@ahmu.edu.cn

 

主持科研项目:

1)安徽省高等学校科学研究重大项目,202410-202709,主持;

2)国家自然科学基金青年科学基金项目,202301-202512,主持;

3)安徽省自然科学基金青年基金项目,202101-202212,主持;

4)安徽医科大学校科研基金,202201-202312,主持;

52020年引进人才博士科研启动经费。

 

近年主要学术论文

(1) Yiman Qin, Guanyi Li, Ling Wang, Guangyuan Yin, Xiang Zhang, Hongxiang Wang, Pengfei Zheng, Wentao Hua, Yan Cheng, Yaxue Zhao, Jiong Zhang. Modular preparation of biphenyl triazoles via click chemistry as non-competitive hyaluronidase inhibitors. Bioorg. Chem. 2024, 146, 107291.

(2) He-Wei Jiang#, Hong Chen#, Yun-Xiao Zheng#, Xue-Ning Wang#, Qingfeng Meng#, Jin Xie#, Jiong Zhang#, ChangSheng Zhang, Zhao-Wei Xu, Zi-Qing Chen, Lei Wang, Wei-Sha Kong, Kuan Zhou, Ming-Liang Ma, Hai-Nan Zhang, Shu-Juan Guo, Jun-Biao Xue, Jing-Li Hou, Zhe-Yi Liu, Wen-Xue Niu, Fang-Jun Wang, Tao Wang, Wei Li, Rui-Na Wang, Yong-Jun Dang, Daniel M Czajkowsky, JianFeng Pei, Jia-Jia Dong, Sheng-Ce Tao. Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.Sci. China Life Sci.2023, 66(8), 1869-1887.

(3) Xuening Wang, Byuri Sim, Hong Chen, Yunxiao Zheng, Junbiao Xue, Lei Wang, Weisha Kong, Kuan zhou, Shujuan Guo, Jingli Hou, Jiong Zhang*, Hewei Jiang*, Shengce Tao*. Identification of sitagliptin binding proteins by affinity purification mass spectrometry. Acta Biochim. Biophys. Sin.2022, 54(10), 1453-1463.

(4) Jiong Zhang, Xiangxiang Zhao, John R. Cappiello, Yi Yang, Yunfei Cheng, Guang Liu, Wenjing Fang, Yinzhu Luo, Yu Zhang, Jiajia Dong, Lixin Zhang, Karl Barry Sharpless. Identification of simple arylfluorosulfates as potent agents against multi-drug resistant bacteria. Proc. Natl. Acad. Sci. U.S.A.2021, 118, e2103513118.

(5) Jiong Zhang, Jiajia Dong. Modular click chemistry library: searching for better functions. Chin. J. Chem.2021, 39, 1025-1027.

(6) Jiong Zhang, Jinyi Zhang, Guiyun Hao, Weixiang Xin, Fei Yang, Mingyan Zhu, Huchen Zhou. Design, synthesis, and structure-activity relationship of 7-propanamide benzoxaboroles as potent anticancer agents. J. Med. Chem. 2019, 62, 6765-6784.

(7) Genyi Meng, Taijie Guo, Tiancheng Ma, Jiong Zhang, Yucheng Shen, Karl Barry Sharpless, Jiajia Dong. Modular click chemistry libraries for functional screens using a diazotizing reagent. Nature2019, 574, 86-89.