吴宝明,博士,副教授,硕士生导师
美国 Morehouse School of Medicine 访问学者(2015.05-2015.11/2018.04-2019.05),中国药理学会会员,安徽省药学会理事。Frontiers in Pharmacology、Biomolecules客座主编;Journal of Clinical and Translational Hepatology 、American Journal of Translational Research 编委;医药导报、世界华人消化杂志编委;国家卫健委“十四五”规划教材《临床药理学》数字编委。主持国家自然科学基金、安徽省自然科学基金、安徽省高等学校自然科学基金、安徽医科大学自然科学研究基金、茶树生物学与资源利用国家重点实验室开放课题、安徽省和安徽医科大学质量工程项目,安徽省第十五批“115”产业创新团队主要成员,发表SCI论文20余篇。国家级精品资源共享课程《临床药理学》的主讲教师,入选《临床药理学》课程思政示范课程国家级教学团队和教学名师,教育部黄大年式教师团队主要成员。
研究方向:抗炎免疫药理学,离子通道药理学。
联系方式:邮箱:wubaoming@ahmu.edu.cn
主持课题:
1. 国家自然科学基金项目:Kv1.3/ Kv1.5介导巨噬细胞的免疫调节在肝纤维化中的机制研究,2016.01-2018.12
2. 安徽省自然科学基金:Kv1.3 介导巨噬细胞免疫功能和糖代谢调节在酒精性肝纤维化中的机制研究,2021.01-2023.12
3.茶树生物学与资源利用国家重点实验室开放课题,皖西南地区绿茶对酒精性肝纤维化的保护作用研究,2021.01-2022.12
4. 安徽医科大学引进人才博士科研启动经费,2020-2024
5.安徽省高等学校自然科学基金,肝纤维化大鼠HSC、KC中TRPM7变化及其机制研究,2012.01-2014.12
6.安徽省教学研究项目,后疫情时代临床药理学教学模式改革的实践与探索,2021.01-2022.12
7.安徽医科大学教改重点项目,以培养综合能力为导向的“临床药理学” 实验教学改革,2011.01-2013.12
8.安徽省转化医学研究院重点项目,基于Kv1.3介导酒精性脂肪性肝炎色氨酸代谢紊乱的药物创新研究,2024.01-2026.12
第一或者通讯作者文章
1. Xie H, Jiang Y, Xiang Y, Baoming Wu, Zhao J, Huang R, Wang M, Wang Y, Liu J, Wu D, Tian D, Bian E. Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia.Neuro Oncol. 2024 (共一,IF=15.9,中科院1区,安医大,Article)
2. Zhang GD, Wang LL, Zheng L, Wang SQ, Yang RQ, He YT, Wang JW, Zhao MY, Ding Y, Liu M, Yang TY, Baoming Wu, Cui H, Zhang L. A novel HDAC6 inhibitor attenuate APAP-induced liver injury by regulating MDH1-mediated oxidative stress. Int Immunopharmacol. 2024 (共通讯,IF=5.6,中科院2区,安医大,Article)
3. Cheng Zhang, Jie Wang, Baoming Wu.Breaking Barriers: Overcoming Low Abundance of miR-122 with E-DDM for Precise Detection in HCC Patients[J]. Sensors and Actuators B: Chemical .2024.(通讯作者,IF=8.4,中科院1区,安医大,Article)
4. Xia G, Li Z, Sheng X, Xie Z, Fang Q, Zhang C, Wang T, Wang Y, Baoming Wu*, Lv X*. Water extract of green tea attenuates alcohol-related hepatitis by inhibiting liver inflammation and gut microbiota disturbance in mice[J]. Food & Function. 2023,14(24):10770-10783.(通讯作者,IF=6.1,中科院1区,安医大,Article)
5. Baoming Wu. Editorial: New compounds, novel targets and mechanism study in inflammation-associated liver diseases.Front Pharmacol[J]. 2022,13:1090504.(第一/通讯作者,IF=5.988,中科院2区,安医大,Review)
6. Zhenni Liu#, Baoming Wu#, Xueqi Liu, Xue Wu, Jiyu Du, Guoqing Xia, Junnan Cai, Hong Zhu, Xiaodong Sheng, Mengda Zhang, Junrui Xu, Tao Xu, Xiongwen Lv. CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence[J]. Int. J. Biol. Sci. 2023 (共一,IF=10.75,中科院2区,安医大,Article)
7. Zhenni Liu, Xue Wu, Qi Wang, Zixuan Li, Xueqi Liu, Xiaodong Sheng, Hong Zhu, Mengda Zhang, Junrui Xu, Xiaowen Feng, Baoming Wu* and Xiongwen Lv*. CD73-adenosine A1R axis regulates the activation and apoptosis of hepatic stellate cells through the PLC-IP3 -Ca2+ /DAG-PKC signaling pathway[J].Frontiers in Pharmacology. 2022,922885(通讯作者,IF=5.988,中科院2区,安医大,Article)
8. Jun-da Liu, Xiongwen Lv , Lei Zhang , Jun Li, Hua Wang, Baoming Wu*. Review on biological characteristics of Kv1.3 and its role in liver diseases[J]. Frontiers in Pharmacology. 2021, 12:652508. (通讯作者,IF=5.988,中科院2区,安医大,Review)
9. Baoming Wu, Bargaineer J, Zhang L, Yang T, Xiong ZG, Leng TD. Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through JNK pathway[J]. Acta Pharmacologica Sinica, 2021. (第一作者,IF=7.169,中科院1区,Morehouse School of Midicine,Article)
10. Baoming Wu, Liu JD, Li YH, Li J. Blockage of Kv1.3 regulates macrophage migration in acute liver injury by targeting δ-catenin through RhoA signaling[J]. IJBS. 2020,16(4):671-681. (第一作者,IF=6.582,中科院2区,安医大,Article)
11. Baoming Wu, Liu JD, Li YH, Li J. Margatoxin mitigates CCl4induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling[J]. Int J Mol Med. 2020,45(1):103-114. (第一作者,IF=4.101,中科院2区,安医大,Article)
12. Baoming Wu, Leng TD, Inoue K, Li J, Xiong ZG. Effect of Redox-Modifying Agents on the Activity of Channelrhodopsin-2[J]. CNS Neurosci Ther. 2017, 23(3):216-221. (第一作者,IF=5.243,中科院1区,安医大,Article)
13. Baoming Wu, Wang XH, Zhao B, Bian EB, Yan H, Cheng H, Lv XW, Xiong ZG, Li J. Electrophysiology properties of Kv Channels in rat peritoneal macrophages[J]. Int J Clin Exp Med. 2013,6(3):166-73.