王学富,博士,副教授,博士生导师
安徽医科大学“优秀教师”, 中国免疫学会青年工作委员会委员,中国生物医学工程学会免疫治疗工程分会青年委员。主持国家自然科学基金、安徽省自然科学基金等多项课题研究,发表SCI论文10余篇。临床药理学国家级教学团队和教育部黄大年式教师团队主要成员,参编全国高等院校药学专业“十三五”规划实验教材。
研究方向:炎症调控机制与靶向治疗、肿瘤免疫逃逸与免疫治疗。
联系方式:wangxuefu@ahmu.edu.cn:
主持课题:
1. 国家自然科学基金项目:孤儿受体GPR35通过代谢重编程调控巨噬细胞极化发挥抗药物性肝损伤作用,2021/01-2024/12
2. 国家自然科学基金项目:犬尿喹啉酸对NLRP3炎症小体活化及相关炎症疾病的调控作用与机制研究,2019/01-2022/12
3. 安徽省自然科学基金:IL-17A诱导CD8+T细胞功能耗竭促进肝癌发展的机制研究, 2017/7-2019/6
4. 安徽医科大学科研提升计划:2020/1-2022/12
部分发表文章:(10篇以内)
1. Molecular Regulation of NK Cell Maturation. Bi J*, Wang X*. Front Immunol. 2020 Aug 11;11:1945
2. Reduced Siglec-7 expression on NK cells predicts NK cell dysfunction in primary hepatocellular carcinoma. Tao L#, Wang S#, Yang L, Jiang L, Li J*, Wang X*. Clin. Exp. Immunol. 2020 Aug;201(2)
3. Cytotoxic immune cell-based immunotherapy for hepatocellular carcinoma. Li J#, Tao L, Wang X*. Hepatoma Res 2020;6:15.
4. IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3. Wang X, Sun R, Hao X, Lian ZX, Wei H, Tian Z. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17409-17418.
5.γδ T cells in liver diseases. Wang X*, Tian Z. Front Med. 2018 Jun;12(3):262-268. Review.
6. Interleukin-28B dampens airway inflammation through up-regulation of natural killer cell-derived IFN-γ. Yan B, Chen F, Xu L*, Wang Y, Wang X*. Sci Rep. 2017 Jun 15;7(1):3556.
7. HMGB1-TLR4-IL23-IL17A axis promotes paraquat-induced acute lung injury by mediating neutrophil infiltration in mice. Yan B, Chen F, Xu L*, Xing J, Wang X*.Sci Rep. 2017 Apr 4;7(1):597.
8. Regulatory T cells ameliorate acetaminophen-induced immune-mediated liver injury. Wang X, Sun R, Chen Y, Lian ZX, Wei H, Tian Z*.Int Immunopharmacol. 2015 Apr;25(2):293-301.
9. High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of γδ T cells with macrophages. Wang X, Sun R, Wei H, Tian Z*.Hepatology. 2013 Jan;57(1):373-84.
10.Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice. Wang X, Qi Z, Wei H, Tian Z, Sun R*.Transpl Immunol. 2012 Mar;26(2-3):156-62.