药剂学
硕士生导师——沈陈林老师
文章来源:药学院    发布时间:2017-12-07

 


沈陈林,博士,校聘副教授,硕士生导师

安徽省药学会药物代谢专业委员会委员,安徽省执业药师协会治疗药物监测药师分会委员,中国CRC专家安徽分会委员。国际专业学术期刊Xenobiotica审稿专家。参与国家自然科学基金、安徽省自然科学基金等多项课题研究,发表SCI论文10余篇。省级精品资源共享课程《中药药剂学》的主讲教师。参编《新药研发的剂量优化》(科学出版社),《定量药理与新药评价》(人民军医出版社)教材。

 

研究方向:药物的吸收转运机制,中药药代动力学,中药复方配伍机制等。

 

联系方式:邮箱:shchlin520@163.com

 

主持课题:

1. 博士科研资助项目,8-叔丁胺基甲基橙皮素(MTBH)在MRP2膜囊泡上转运机制及其对CYP450 3A42E1的影响,2016.12-2019.12

2. 安徽医科大学校基金,基于MDCK-HPLC联用技术的四物汤中有效成分梓醇、阿魏酸、芍药苷和川芎嗪吸收研究及其机制探讨,2016.12-2019.12

 

部分发表文章:(10篇以内)

1. Chenlin Shen#, Ruonan Chen, Zhengyue Qian, Xiaoming Meng, Tingting Hu, Yangyang Li, Zhaolin Chen, Cheng Huang, Chaojie Hu, Jun Li*. Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2. Eur J Pharm Sci. 2015 Oct 12; 78: 214-24. (IF=3.35)

2. Chenlin Shen#, Ruonan Chen, Zhengyue Qian, Cheng Huang, Xiaoming Meng, Taotao Ma, Zhaolin Chen, Xiaohui Huang, Lan Li, Hongmei Zang, Jun Li*. A HPLC−MS/MS method for the quantitation of free, conjugated, and total HDND-7, a novel hesperetin derivative, in rat plasma and tissues: Application to the pharmacokinetic and tissue distribution study. J Pharm Biomed Anal. 2016 Jan 25; 118: 149-60. (IF=2.979)

3. Chenlin Shen#, Xiaohui Huang*, Jun Li*, Ping Zhang, Lin Li, Wei Zhang, Tingting Hu, Faustina Pappoe, Jihan Huang, Haiqin Tang. Pharmacokinetic and pharmacodynamic interactions of aspirin with warfarin in beagle dogs. Xenobiotica. 2016 Jun; 46(6): 530-41. (IF=2.199)

4. Chenlin Shen#, Zhengyue Qian, Ruonan Chen, Xiaoming Meng, Tingting Hu, Zhaolin Chen, Yangyang Li, Cheng Huang, Chaojie Hu, Jun Li*. Single dose oral and intravenous pharmacokinetics and tissue distribution of a novel hesperetin derivative MTBH in rats. Eur J Drug Metab Pharmacokinet. 2015 Aug 9. (IF=1.563)

5. Chenlin Shen#, Xiaohui Huang*, Jihan Huang, Xuefeng Xie, Ping Zhang, Lin Li, Jiancai Zhou, Songtao Tang, Shu Gao, Haiqin Tang. Development and validation of a RP-HPLC method for simultaneous determination of warfarin enantiomers, aspirin and salicylic acid in beagle plasma: application to pharmacokinetic study. Lat. Am. J. Pharm. 32(5): 679-87 (2013). (IF=0.372)

6. Xiaqin Wang#, Chenlin Shen#, Bangning Wang*, Xiaohui Huang*, Zhangle Hu, Jun Li. Genetic polymorphisms of CYP2C19*2 and ABCB1 C3435T affect the pharmacokinetic and pharmacodynamic responses to clopidogrel in 401 patients with acute coronary syndrome. Gene. 2015 Mar 10; 558(2): 200-7. (IF=2.138).

7. Gen-xiang Rong1, Chenlin Shen1, Jun Li. Comparison of the Pharmacokinetic Properties after Intra-Articular and Intravenous Administration of Tranexamic Acid in Rabbits. Pakistan Journal of Pharmaceutical Sciences. (IF=0.682) [Article], received. 共同第一作者

8. Chaojie Hu#, Xiaoming Meng, Cheng Huang, Chenlin Shen, Jun Li*. Frontline Science: ATF3 is responsible for the inhibition of TNF-α release and the impaired migration of acute ethanol-exposed monocytes and macrophages. J Leukoc Biol. 2016 Jun 3. (IF=4.705)

9. Zhengyue Qian#, Cheng Huang, Chenlin Shen, Xiaoming Meng, Zhaolin Chen, Tingting Hu, Yangyang Li, Jun Li*. The permeability characteristics and interaction of the main components from Zhizi Bopi decoction in the MDCK cell model. Xenobiotica. 2016 Aug; 46(8): 733-42. (IF=2.199)

10. Jihan Huang#, Xiaohui Huang#*, Kun Wang, Jianchun Li, Xuefeng Xie, Chenlin Shen, Lujin Li, Qingshan ZhengBioequivalence evaluation of two formulations of pidotimod using a limited sampling strategy. Biomed Pharmacother. 2013 Jul; 67(6): 475-80. (IF=2.023)