药物化学
硕士生导师--邸磊
文章来源:药学院    发布时间:2021-09-03


邸磊,博士,硕士生导师

2019年博士毕业于中国药科大学基础医学与临床药学学院药理学专业,开展天然活性成分分离、结构鉴定、活性筛选工作及作用机制研究工作。研究兴趣主要围绕中草药与药用动物活性部位抗病物质基础及成药性相关研究。主持安徽省高等学校省级自然科学研究项目1项,发表文章近20篇,其中SCI收录论文18篇。

研究方向:天然药物化学中药药效物质基础及作用机制的研究


联系方式:dilei163@163.com


主持课题:

1. 安徽省高等学校省级自然科学研究项目,黄花败酱中新木脂素及其衍生物抗转移性前列腺癌活性研究,项目编号:060108720256万,2021/1/1--2022/12/31,项目负责人。

代表性论文:

1. Di Lei, Liu Lijuan, Yan Yongming, Fu Rong, Li Yi, Xu Ying, Cheng Yongxian*, Wu Zhaoqiu*. Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ/BMP signaling in triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 2019, 38(1): 134-148.

2. Fu Rong#, Han Chenfeng#, Ni Ting#, Di Lei#, Liu Lijuan, Lv Wencong, Bi Yanran, Jiang Nan, He Yin, Li Hongmei, Wang Shui, Xie Hui, Chen Baoan, Wang Xiaosheng, Weiss Stephen J, Lu Tao, Guo Qinglong, Wu Zhaoqiu*. A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours. Nature Communications. 2019, 10(1): 3210-3227.

3. Di Lei, Shi Yanni, Yan Yongming, Jiang Liping, Hou Bo, Wang Xinlong, Zuo Zhili*, Chen Yongbin, Yang Cuiping*, Cheng Yongxian*. Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties. Rsc Advances, 2015, 5(87): 70985-70991.

4. Di Lei, Yan Guoqing, Wang Lingyu, Ma Wei, Wang Kaijin*, Li Ning*. Two new neolignans from Patrinia scabra with potent cytotoxic activity against HeLa and MNK-45 cells. Archives of Pharmacal Research, 2013, 36(10): 1198-1203.

5. Wang Xinlong#, Zhou Fengjiao#, Dou Man#, Yan Yongming, Wang Shumei, Di Lei*, Cheng Yongxian*. Cochlearoids F-K: Phenolic meroterpenoids from the fungus Ganoderma cochlear and their renoprotective activity. Bioorganic & Medicinal Chemistry Letters, 2016, 26(22): 5507-5512.

6. Luo Qi#, Tian Lei#, Di Lei#, Yan Yongming, Wei Xiaoyi, Wang Xinfang, Cheng Yongxian*. (+/-)-Sinensilactam A, a pair of rare hybrid metabolites with Smad3 phosphorylation inhibition from Ganoderma sinensis. Organic Letters, 2015, 17(6): 1565-1568.

7. Luo Qi#, Di Lei#, Dai Weifeng, Lu Qing, Yan Yongming, Yang Zhuliang, Li Rongtao, Cheng Yongxian*. Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity. Organic Letters, 2015, 17(5): 1110-1113.

8. Dou Man#, Di Lei#, Zhou Lili, Yan Yongming, Wang Xinlong, Zhou Fengjiao, Yang Zhuliang, Li Rongtao*, Hou Fanfan*, Cheng Yongxian*. Cochlearols A and B, polycyclic meroterpenoids from the fungus Ganoderma cochlear that have renoprotective activities. Organic Letters, 2014, 16(23): 6064-6067.