王学富，教授，博导，药学院副院长，中国免疫学会青年工作委员会常务委员，中国生物医学工程学会免疫治疗工程分会青年委员，中国药理学会抗炎免疫药理专业委员会委员，安徽省药理学会抗炎免疫药理学专业委员会委员。发表SCI论文40余篇，主要研究结果发表于PNAS、Hepatology、Acta Pharm Sin B等学术刊物，主持国家自然科学基金、安徽省自然科学基金等，入选安徽省高校杰青项目、安徽省优青项目、高校优秀青年人才支持计划、安徽医科大学青年拔尖人才计划等。

研究方向：免疫调控、肿瘤免疫与炎症免疫

联系方式：wangxuefu@ahmu.edu.cn

主持课题

1. 国家自然科学基金项目 2024/01-2027/12

2. 国家自然科学基金项目 2021/01-2024/12

3. 国家自然科学基金项目 2019/01-2022/12

4. 安徽省高校杰青项目  2023/09-2026/09

5. 安徽省优青项目    2021/01-2023/12

部分文章

1.G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes. Wei X, Yin F, Wu M, Xie Q, Zhao X, Zhu C, Xie R, Chen C, Liu M, Wang X, Ren R, Kang G, Zhu C, Cong J, Wang H, Wang X. Acta Pharm Sin B. 2023 Mar; 13(3):1128-1144. 

2.A2AR limits IL-15-induced generation of CD39⁺ NK cells with high cytotoxicity. Kang G, Zhao X, Sun J, Cheng C, Wang C, Tao L, Zong L, Yin W, Cong J, Li J, Wang X. Int Immunopharmacol. 2023 Jan; 114:109567.

3.Localization and density of tertiary lymphoid structures associate with molecular subtype and clinical outcome in colorectal cancer liver metastases. Zhang C, Wang XY, Zuo JL, Wang XF, Feng XW, Zhang B, Li YT, Yi CH, Zhang P, Ma XC, Chen ZM, Ma Y, Han JH, Tao BR, Zhang R, Wang TQ, Tong L, Gu W, Wang SY, Zheng XF, Yuan WK, Kan ZJ, Fan J, Hu XY, Li J, Zhang C, Chen JH. J Immunother Cancer. 2023 Feb;11(2): e006425.

4.Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35. Sun T, Xie R, He H, Xie Q, Zhao X, Kang G, Cheng C, Yin W, Cong J, Li J, Wang X. Front Immunol. 2022 Oct 13; 13:1019365.

5.PD-1 blockade improves the anti-tumor potency of exhausted CD3+CD56+ NKT-like cells in patients with primary hepatocellular carcinoma. Tao L#, Wang S#, Kang G#, Jiang S, Yin W, Zong L, Li J, Wang X. Oncoimmunology. 2021 Nov 9;10(1):2002068.

6.Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia. Yang L, Feng Y, Wang S, Jiang S, Tao L, Li J, Wang X. Int Immunopharmacol. 2021 Jul 14; 99:107965. 

7.Molecular Regulation of NK Cell Maturation.  Bi J, Wang X. Front Immunol. 2020 Aug 11; 11:1945 

8.Reduced Siglec-7 expression on NK cells predicts NK cell dysfunction in primary hepatocellular carcinoma. Tao L#, Wang S#, Yang L, Jiang L, Li J*, Wang X*. Clin. Exp. Immunol. 2020 Aug;201(2) IF=4.33

9.IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3. Wang X, Sun R, Hao X, Lian ZX, Wei H, Tian Z. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17409-17418.

10.High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of γδ T cells with macrophages. Wang X, Sun R, Wei H, Tian Z. Hepatology. 2013 Jan;57(1):373-84.